There are multiple origins and meanings for the name Adrian:
1. Latin (Hadrianus) from ancient Greek (Αδριανός) [Adrianos] etymology (definition) - "Adriatic, Hadrian; from Adria, from the Adriatic sea"
In ancient Greece name Adrian was one of the epithets of Zeus
2. Comes from the Greek name Andrew meaning - "manly"
3. Old Germanic - "Slav"
St. Adrian and St. Natalia were pagans who were married for one year prior to their martyrdom, and lived in Nicomedia during the time of Emperor Maximian in the early fourth century. The emperor promised a reward to whomever would inform on Christians to bring them to trial. The denunciations then began, and twenty-three Christians were captured in a cave near Nicomedia.